Uranium Exerts Acute Toxicity by Binding to Pyrroloquinoline Quinone Cofactor
نویسندگان
چکیده
منابع مشابه
Pyrroloquinoline Quinone as Cofactor in Galactose Oxidase
Galactose oxidase from Dactylium dendroides was shown to contain one molecule of covalently bound pyrroloquinoline quinone (PQQ)/enzyme molecule. From the spectroscopic characteristics reported for the enzyme forms, a mechanistic role for PQQ could be deduced. In analogy with other quinoproteins, the initial formation of a PQQ-substrate adduct is proposed. Following internal hydrogen transfer, ...
متن کاملPyrroloquinoline Quinone a Redox Cofactor and Its Involvement in Biological System
This paper highlights some features, which describe the characterization and physiological importance of Pyrroloquinoline quinone (PQQ), discovered more than forty years ago. Mechanism of biosynthetic pathway of PQQ is described based on sequence analysis and homology models. But still now all activities of PQQ are not discovered. PQQ is not only a bacterial redox cofactor in alcohol oxidation ...
متن کاملPea (Pisum sativum) diamine oxidase contains pyrroloquinoline quinone as a cofactor.
Diamine oxidase was prepared from pea (Pisum sativum) seedlings by a new purification procedure involving two h.p.l.c. steps. We studied the optical and electrochemical properties of the homogeneous enzyme and also analysed the hydrolysed protein by several methods. The data presented here suggest that the carbonyl cofactor of diamine oxidase is firmly bound pyrroloquinoline quinone.
متن کاملProduction of pyrroloquinoline quinone by using methanol-utilizing bacteria.
A large number of methanol-utilizing bacteria were screened for extracellular production of pyrroloquinoline quinone (PQQ) by using methanol as the carbon and energy sources. Of the bacteria selected, Hyphomicrobium sp. strain TK 0441 was examined for PQQ production by using a jar fermentor. The amount of PQQ in the broth and the level of methanol dehydrogenase activity in the cells were increa...
متن کاملProduction and Radioprotective Effects of Pyrroloquinoline Quinone
Pyrroloquinoline quinone (PQQ) was produced by fermentation of the Methylovorus sp. MP688 strain and purified by ion-exchange chromatography, crystallization and recrystallization. The yield of PQQ reached approximately 125 mg/L and highly pure PQQ was obtained. To determine the optimum dose of PQQ for radioprotection, three doses (2 mg/kg, 4 mg/kg, 8 mg/kg) of PQQ were orally administrated to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Science & Technology
سال: 2011
ISSN: 0013-936X,1520-5851
DOI: 10.1021/es101754x